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Ondansetron Zofran vs. Dramamine: What's the difference. What are ondansetron and Dramamine. Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by cancer chemotherapy. Chemotherapy agents increase secretion of serotonin, which stimulates serotonin 5-HT3 receptors in the brain, causing nausea and vomiting.

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Zofran Ondansetron is a prescription antiemetic medication that is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy or radiation treatment. This medication works by blocking the action of serotonin that may cause nausea and vomiting. This medication may be taken with or without food as directed by your doctor.

   
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