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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Reason for the Shortage Glenmark did not provide a reason for the shortage. Mylan did not provide a reason for the shortage. Mylan discontinued their unit dose presentations in has Calan SR tablets available. Estimated Resupply Dates Glenmark has verapamil mg extended-release tablets in count bottles on back order and the company cannot estimate a release date.
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Moritz (taken for 2 to 4 years) 09.02.2016
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Verapamil, a calcium channel blocker, is classified as a class IV anti-arrhythmic agent. It is used in the treatment of hypertension, as an important therapeutic agent for angina pectoris, ischemic heart disease, hypertension and hypertrophic cardiomyopathy. Many in-vivo studies have been carried out to find out the effects on concurrent use of calcium channel blocker with various groups of drugs.
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One main reason for the observation of weak staining is the activity of efflux pumps in the sample. The addition of a broad spectrum efflux pump inhibitor such as verapamil has generally a positive effect on the signal intensity. If the fluorescence signal of your samples is weak, it is recommended to repeat the staining in the presence of Verapamil.
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