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A possible explanation for the failure of this trial was enzymatic induction of clearance of risperidone and its principal active metabolite, 9-hydroxyrisperidone, by carbamazepine in the subgroup of patients receiving combined therapy with these drugs, resulting in subtherapeutic plasma concentrations of risperidone and 9-hydroxyrisperidone.

All patients in this study were treated with open-label extended-release IM risperidone therapy for 26 weeks.


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