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Digoxin vs. What are digoxin and metoprolol? Digoxin is a cardiac glycoside used to treat adults with mild to moderate congestive heart failure and to treat abnormally rapid atrial rhythms such as atrial fibrillation, atrial flutter, and atrial tachycardia. Digoxin is also used to increase myocardial contractility in pediatric patients with heart failure. Digoxin increases the force of contraction of the heart muscle by inhibiting the activity of an enzyme ATPase that controls movement of sodium, calcium, and potassium into the heart muscle. Calcium controls the force of contraction. Inhibiting ATPase increases calcium in the heart muscle, which increases the force of heart contractions. Digoxin also slows electrical conduction between the atria and the ventricles of the heart, which is useful in treating abnormally rapid atrial rhythms. Metoprolol is a beta-blocker beta-adrenergic blocking agent used to treat high blood pressure hypertension, heart pain angina, congestive heart failure, hyperthyroidism, abnormal heart rhythms, and some neurologic conditions.

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