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The first patient was enrolled on September 10, and the last patient concluded the study on May 4, Patients were excluded if they had a history of ketoacidosis or had unstable or rapidly progressive diabetic retinopathy, nephropathy, or neuropathy; impaired hepatic or renal function; or severe anemia. Patients with serious cardiovascular disease CVD or cerebrovascular conditions within 6 months before study enrollment were also excluded. Women who were pregnant or breastfeeding or of childbearing potential and not taking adequate contraceptive precautions were also excluded. A description of how randomization and medication compliance were assessed can be found in our previous work.
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A popular diabetes drug sometimes taken to slow ageing may diminish some of the expected health benefits of aerobic exercise in healthy older adults, according to a new report. The results raise questions about the relationship of pills and physical activity in healthy ageing and also whether we know enough about how drugs and exercise interact. The results are particularly disconcerting given that healthy, active people may be considering taking the drug to slow ageing.
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