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Sections without translation will be in English. Akerlund Methods. Inclusion: regularly occurring menstrual pain requiring medication Exclusion: lactation; history or sign of severe generalised allergic or gastrointestinal disease; use of analgesics Age: range 17 to 45, median 26 Location: Sweden. Ketoprofen mg Naproxen mg Single dose Duration: 2 cycles, 1 treatment per cycle. The ketoprofen group initially had higher pain levels Data on adverse effects reports number of symptoms but not number of women affected. Inclusion: primary dysmenorrhoea Exclusion: menstrual irregularities; history peptic ulcer, renal or blood disorders; pregnant; use of other medicines for condition Age: 17 to 33, mean Piroxicam 20 mg, placebo 2 tablets per day for 2 days, then 1 tablet per day until symptoms or menses subsided Duration: 4 cycles per participant, cycles in total.
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Study selection Randomised controlled trials assessing the efficacy and tolerability of drugs versus placebo or other treatment for sciatica. Pain and disability outcomes were converted to a common 0 to scale. Data were pooled with a random effects model, and the GRADE approach was used in summary conclusions. The evidence to judge the efficacy of non-steroidal anti-inflammatory drugs NSAIDs, corticosteroids, antidepressants, anticonvulsants, muscle relaxants, and opioid analgesics ranged from moderate to low quality. Most of the pooled estimates did not favour the active treatment over placebo.
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