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In these studies, greatest increase in BMD occurred in the first year of therapy and only maintenance or smaller increases in BMD were reported in the second year of therapy with alendronate. In addition, the efficacy of alendronate reportedly was not affected by age, gender, race, underlying disease, previous duration or current dosage of corticosteroid therapy, baseline BMD, baseline bone turnover or concomitant administration of other drugs.
Bone histology was normal in several patients receiving alendronate 10 mg daily for 1 year who underwent bone biopsy.
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