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Neostigmine: Major Neostigmine and pyridostigmine are both parasympathomimetics. Neuromuscular blockers: Major Cholinesterase inhibitors may be used to reverse the actions of nondepolarizing neuromuscular blockers; however, cholinesterase inhibitors may also prolong the neuromuscular blocking effects if given with depolarizing neuromuscular blockers, as these drugs are metabolized by acetylcholinesterase.
Nonsteroidal antiinflammatory drugs: Moderate NSAIDs may cause additive pharmacodynamic GI effects with cholinesterase inhibitors, leading to gastrointestinal intolerance.
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