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Dapsone, also known as diaminodiphenyl sulfone DDS, is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. Severe side effects may include a decrease in blood cells, red blood cell breakdown especially in those with glucosephosphate dehydrogenase deficiency GPD, or hypersensitivity. Dapsone was first studied as an antibiotic in Dapsone is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. Dapsone by mouth was one of the first medications used to treat moderate to severe acne vulgaris, and is still occasionally prescribed for the treatment of severe cases.

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