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December 20, 2019


It is easily taken by young children, in contrast to the extremely repulsive crystalline Chloromycetin chloramphenicol. The absorption rate for Chloromycetin palmitate is slower than that for crystalline Chloromycetin and the maximum blood concentration, which for crystalline Chloromycetin is obtained about 2 hours after the fasting administration, is not reached until 1 hour later for Chloromycetin palmitate. A further retardation of absorption takes place if the drug is not administered fasting. The maximum blood concentration of crystalline Chloromycetin is three times higher than the maximum values for the palmitate of the same dosage. In order to obtain a more rapid initial rise of the blood concentration the first dose of Chloromycetin palmitate should be given with a single dose of crystalline Chloromycetin approx.

With an accout for my. Chloramphenicol is effective against a wide variety of microorganisms; it is still very widely used in low income countries because it is exceedingly cheap, but has fallen out of favour in the West due to a very rare but very serious side effect: aplastic anemia. In the West, the main use of chloramphenicol is in eye drops or ointment for bacterial conjunctivitis. Chloramphenicol has recently been discovered to be a life saving cure for chytridiomycosis in amphibians. Half the dose is used in premature babies or neonates, because they do not metabolise the drug as effectively. In some countries, chloramphenicol is sold as chloramphenicol palmitate ester. Chloramphenicol palmitate ester is inactive, and is https://www.mensjournal.com hydrolysed to active chloramphenicol in the small intestine. There is no difference in bioavailability between chloramphenicol and chloramphenicol palmitate. The intravenous IV preparation of chloramphenicol is the succinate ester, because pure chloramphenicol does not dissolve in water.

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