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The subsequent sample preparation method was same as the method of plasma sample preparation, and the concentration of oridonin was determined by LC-MS. The pharmacokinetic parameters, including the area under the plasma concentration-time curve AUC, maximal plasma concentration C max, the time for the maximal plasma concentration T max, and the mean residence time MRT were calculated using the DAS 3.

The differences between the mean values were analysed for significance using a one-way analysis of variance ANOVA.


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