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Indomethacin suppositories are contraindicated in patients with a history of proctitis or recent rectal bleeding. Rectally administered indomethacin should be used with caution in patients with hemorrhoids, anal, or rectal inflammation.

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Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug NSAID commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It does this by inhibiting cyclooxygenase, an enzyme that catalyzes the production of prostaglandins. It was patented in and approved for medical use in For instance, indometacin inhibits both cyclooxygenase-1 and cyclooxygenase-2, which then inhibits the production of prostaglandins in the stomach and intestines responsible for maintaining the mucous lining of the gastrointestinal tract. Indometacin, therefore, like other non-selective https://www.anthem.com COX inhibitors can cause peptic ulcers.

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