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In vivo data, although promising, is currently limited to one study with considerable limitations. Further research should address the optimal dose and duration of treatment, and explore side effects and long-term outcomes. There is a higher risk of side effects in the presence of renal and liver impairment, and there have been isolated reports of COVID disease-causing renal and hepatic injury. Contraindications for the use of these drugs must be checked for each individual before treatment. Empirical evidence suggests that hydroxychloroquine has a better safety profile, and it might therefore be preferable to focus research efforts on this less toxic metabolite.

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