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Antenatal corticosteroids ACS are the standard of care for maturing the fetal lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains nonoptimized, and there is little understanding of how different treatment-to-delivery intervals may affect treatment efficacy. The durability of a lung maturational response is important because the majority of women treated with antenatal corticosteroids do not deliver within the widely accepted 1- to 7-day window of treatment efficacy. We used a sheep model to test the duration of fetal exposures for efficacy at delivery intervals from 1 to 10 days. Animals receiving the clinical treatment were randomised to receive either a single injection of 0. Negative control animals were treated with saline solution.
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Marianne (taken for 2 to 4 years) 17.01.2016
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Preterm birth is characterized by severe lung immaturity that is frequently treated antenatally or postnatally with the synthetic steroid betamethasone. The underlying cellular targets and pathways stimulated by betamethasone in the fetal lung are poorly defined.
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Acute scrotal pain or swelling. Children requiring care above the level of comfort of the local hospital or their treating medical team. Penis and foreskin care.
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There are minimal safety data to recommend this treatment. This study evaluated the safety of betamethasone nasal irrigation by measuring its impact on endogenous cortisol levels. The impact on pre- and post-intervention serum and hour urinary free cortisol was assessed.
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